The crowd cheered wildly when Bolt won in his first 100 of the year, giving him a standing ovation after the race that had two false starts. The time was the fastest in the world this year.
“It's always a joy,” Bolt said. “I was very happy to come here and see all the people who came out.”
The crowd included the Caribbean country's prime minister, Portia Simpson Miller.
Even before the race, the confident Bolt got the hometown crowd going with a quick “To Di World” pose, in which he points to the sky as if he's about to shoot an arrow into the sky.
In the Beijing Olympics four years ago, Bolt won gold medals and set world records in the 100 and 200 and helped Jamaica win and set a world record in 400 relay.
Jamaica's Michael Frater was second in 10.00.
In the night's final race, Yohan Blake of Jamaica dominated the 200, with 19.91, the best time in the world this season.
Blake owns the world's second-fastest time in the 200 - the 19.26 he ran last September.
Jamaica's Asafa Powell, the former world record holder in the 100 meters, withdrew from the Saturday meet with a groin injury. He had been scheduled to race Blake in the 200.
It wasn't just Jamaicans who clocked world beating times on Saturday. American Carmelita Jeter wowed the crowd by winning the women's 100 in 10.81, the fastest time in the world this season.
American Bershawn Jackson won the 400 hurdles in 48.73 seconds, and Ben Bruce dominated the 3,000 steeplechase, finishing in 8:34.17 to beat fellow American Donnie Cowart.